Tofacitinib 2 Cream/Lotion Compounded / Tofacitinib citrate (xeljanz) is an oral, small molecule drug used to treat adults with moderate to severe active rheumatoid arthritis (ra), active psoriatic arthritis, moderate to severe ulcerative colitis, and children ages 2 an older with active polyarticular juvenile idiopathic arthritis.tofacitinib works by.